Sequence can be played with 2 to 8 players. These players gets equally divided into two, three or four teams.
Each team has separate color chips. There can be maximum of four players in single team and maximum of four teams in this game.

Each card is pictured twice on the game board, and Jacks (while necessary for game strategy) do not appear on the board.

The player chooses a card from their hand, and places a chip on one of the corresponding spaces of the game board (Example: they choose Ace of Diamonds from their hand and place a chip on the Ace of Diamonds on the board). Jacks have special powers. Two-Eyed Jacks can represent any card and may be used to place a chip on any open space on the board. One-Eyed Jacks can remove an opponent's token from a space. Players may use the Two-Eyed Jacks to complete a row or block an opponent, and One-Eyed Jacks can remove an opponent's advantage. One-Eyed Jacks cannot be used to remove a marker chip that is already part of a completed sequence; once a sequence is achieved by a player or team, it stands.

Once player has played his/her turn, player gets a new card from the deck.

A player may place chips on either of the appropriate card spaces as long as it is not already covered by an opponent's marker chip.

If a player possesses a card which does not have an open space on the game board, the card is considered "dead" and may be exchanged for a new card. When it is their turn, they place the dead on card on the discard pile, announce they are turning in a dead card, and take a replacement (one card per turn). Then they proceed to play their normal turn.

In this game, there are multiple boosters which makes the game more interesting.